The progress of scientific research does require innovation and courage, but ethical review does not exist to hinder scientific exploration, but to protect the rights and interests of all relevant parties, including experimental participants, researchers, and the interests of society as a whole. Bypassing ethical review for controversial experiments may have serious consequences, including but not limited to： 1. **Harm to participants**: The core purpose of the ethical review is to ensure that the experiment will not cause unnecessary physical or psychological harm to participants. Bypassing this procedure may expose participants to unverified risks. 2. **Legal consequences**: In many countries and regions, it is illegal to conduct human or animal experiments without the approval of the ethics review committee, which may lead to legal proceedings, fines or even criminal liability. 3. **Damage to academic reputation**: Once it is found that ethical review is bypassed, the academic reputation of researchers may be irrevocably damaged and may even be banned from future research work. 4. **Loss of social trust**: The credibility of scientific research depends on public trust. Once the act of bypassing ethical review is exposed, it will not only damage the reputation of individuals, but also affect the image of the entire scientific community. 5. **Invalidity of research results**: Most reputable journals and academic conferences require research to pass ethical review before it can be published or displayed. Bypassing ethical review may prevent your research results from being recognized by academia. ### Recommended practice： -**Communicate with the Ethics Review Committee**: If you think that although your experimental design is controversial, it has important scientific value, you can fully communicate with the Ethics Review Committee. They may help you adjust the experimental design so that it is carried out in accordance with ethical standards. -**Seek peer review**: Before submitting for ethical review, you can discuss your experimental design with your peers and listen to their opinions and suggestions. This will help you identify and solve potential ethical problems in advance. -**Consider alternatives**: If some experiments do not pass the ethical review, you can consider using alternative methods (such as computer simulation, in vitro experiments, etc.) to partially achieve your research goals. There is no contradiction between scientific innovation and ethical responsibility. Truly groundbreaking research is often done under the premise of strict compliance with ethical norms. Solving ethical issues through legitimate means can not only protect yourself and participants, but also add credibility and influence to your research. If you have questions about the specific requirements or processes of the ethics review, you can further consult your organization's ethics committee or related experts.