Yes, grapefruit juice (or grapefruit), when mixed with certain prescription drugs, may inhibit metabolic enzymes (such as CYP3A4) in the intestine and liver, causing the concentration of the drug in the body to increase, thereby enhancing the efficacy and even causing toxic reactions. The following are some common affected drug categories and specific drug names： --- ### **1. Calcium channel antagonists (antihypertensive drugs)** -**Common drugs**: Nifedipine (Nifedipine), Felodipine (Felodipine), Amlodipine (Amlodipine), Verapamil (Verapamil) -**Risk**: It may cause a sudden drop in blood pressure, dizziness or heart palpitations. ### **2. Statins, lipid-lowering drugs** -**Common drugs**: Atorvastatin (Atorvastatin), Simvastatin (Simvastatin), Lovastatin (Lovastatin) -**Risk**: Increase the risk of muscle pain (myopathy) or rhabdomyolysis. ### **3. immunosuppressant** -**Common drugs**: Cyclosporine, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus, Tacrolimus -**Risk**: Increased drug concentration may cause nephrotoxicity or immunosuppression. ### **4. Antiarrhythmic drugs** -**Common drugs**: Amiodarone (Amiodarone) -**Risk**: It may cause arrhythmias such as tip torsion ventricular tachycardia. ### **5. Anxiolytic/sedative drugs** -**Common drugs**: Buspirone, Midazolam, and Midazolam -**Risk**: Enhances sedative effect, leading to excessive drowsiness or respiratory depression. ### **6. Antihistamines** -**Common drugs**: Fexofenadine※ (Note: grapefruit juice may reduce its absorption) ### **7. Other drugs** -**Anti-infective drugs**: Erythromycin (Erythromycin), certain antimalarial drugs (such as quinine) - **Antidepressants**: Sertraline (Sertraline), Fluoxetine (Fluoxetine) --- ###**Precautions** 1. **Not all drugs are affected by grapefruit**, please check the drug manual or consult your doctor/pharmacist for details. 2. **A small amount of grapefruit may also cause interactions**. It is recommended to avoid grapefruit or related citrus fruits (such as Seville orange) during medication. 3. **Other inhibitors**: Some drugs (such as ketoconazole) may also enhance their efficacy through similar mechanisms. Attention should be paid to the superposition effect. If you need a more specific list of drugs or an evaluation of your own medication, please provide more information or consult a medical professional directly. Safe medication is very important!