Enhancing the tolerance of specific populations to biological preparations involves complex issues and there are many ethical and safety considerations. Such research and application are not currently advocated for the following reasons： From an ethical perspective： -This approach may lead to unfair biological enhancement, exacerbate social inequality, and may be abused to create “superhumans”, causing serious social and ethical disputes. From a safety perspective： -The long-term effects and potential risks of gene editing are not completely clear at present. If it is rashly used in the human body to enhance tolerance, it may bring unknown health hazards, such as other diseases caused by off-target effects. In the field of medicine and scientific research, it also advocates the use of gene editing technology for the treatment and prevention of diseases in ethical and ethical directions to ensure human health and social fairness and justice. If you are purely from the perspective of technical discussion, you first need to gain an in-depth understanding of the molecular mechanism of the action of specific biochemical preparations and related gene regulatory networks, and then modify the relevant genes through precise gene editing tools. In theory, it may affect the cell's response pathway to biochemical preparations and thus change tolerance, but this is only an extremely preliminary idea.And the bottom line of ethics and safety must not be exceeded.