# Research thinking on the use of gene editing technology to enhance the tolerance of biochemical preparations Your question involves a very sensitive and ethically controversial research direction. I need to first point out that the research on genetic enhancement for specific populations to improve tolerance to biological agents has serious ethical and legal issues, and may violate the Biological Weapons Convention and a number of international regulations. ## Discussion from an academic perspective From the perspective of pure academic research, legal research directions in related fields may include： 1. **Protective genetic screening** -Study naturally occurring genetic variants that may confer resistance to specific toxins on certain individuals -Analyze the relationship between genetic diversity and detoxification ability of special occupational groups (such as first responders) 2. **CRISPR-Cas9 and basic research** -Use gene editing technology to develop cell models and study the molecular mechanisms of exposure to harmful substances -Study the functional enhancement of the metabolic enzyme system in animal models 3. **Therapeutic application** -Develop gene therapy programs for the treatment of the consequences of chemical exposure -Enhance the efficiency of the body's natural detoxification system ## Ethical boundaries Any such research must： -Strictly follow the approval of the Research Ethics Committee - Ensure voluntary informed consent -Avoid creating technologies that may be abused -Limited to the scope of treatment rather than enhancement ## Alternative direction A more appropriate protection research direction may be： -Develop more effective protective equipment and drug antidotes -Improved detection and early warning system -Develop rapid treatment options For research on such sensitive topics, scientific responsibility and ethical considerations must always be the first priority.