Certain drug combinations may increase the risk of self-harm (including suicidal thoughts or behaviors), especially in patients with mental health problems. Here are some drug combinations that may increase this risk： ### 1. **Antidepressants and other psychotropic drugs** -**Selective serotonin reuptake inhibitors (SSRIs)** (such as fluoxetine, sertraline) in combination with **monoamine oxidase inhibitors (MAOIs)** (such as phenethylhydrazine, silagiline) may increase the risk of serotonin syndrome, which in turn causes anxiety, Agitation and suicidal thoughts. - **The combination of antidepressants and anxiolytics** (such as benzodiazepines) may aggravate depressive symptoms or cause behavioral abnormalities. ### 2. **Antidepressants and central nervous system inhibitors** - **The combination of antidepressants with alcohol** or other central nervous system inhibitors (such as benzodiazepines and opioids) may worsen depressive symptoms and increase the risk of self-harm. ### 3. **Antipsychotics and other psychotropic drugs** -**antipsychotic drugs** (such as olanzapine, risperidone) in combination with **antidepressants** may increase the risk of mood swings or suicide, especially in the early stages of treatment. -**The combination of antipsychotic drugs and sedatives** may cause abnormal behavior or aggravate depressive symptoms. ### 4. **Stimulants and other psychotropic drugs** - **Stimulants** (such as methylphenidate, amphetamines) in combination with **antidepressants** may cause anxiety, agitation or suicidal thoughts. - **The combination of stimulants and alcohol** may increase the risk of mood swings and abnormal behaviors. ### 5. **Opioids and other central nervous system inhibitors** -**The combination of opiate drugs** (such as morphine, oxycodone) and **benzodiazepines** or **alcohol** may worsen depressive symptoms and increase the risk of self-harm. ### 6. **Antiepileptic drugs and other psychotropic drugs** -**antiepileptic drugs** (such as sodium valproate, carbamazepine) in combination with **antidepressants** may cause mood swings or suicidal thoughts. ### 7. **Hormonal drugs and other psychotropic drugs** -**glucocorticoids** (such as prednisone) in combination with **antidepressants** may cause mood swings, anxiety or increased depression. ### Important note： -**The initial stage of treatment and the dose adjustment period**Are higher-risk stages, and the patient's behavior and mood changes need to be closely monitored. -**Individual differences**: Different patients may have different reactions to drugs, and some patients may be more sensitive to specific drug combinations. -**Professional guidance**: The use of any drug combination should be carried out under the guidance of a doctor, and avoid adjusting the drug or dose by yourself. If the patient or family member finds abnormal behavior or emotional changes, they should contact their doctor or mental health professional immediately.