It is theoretically possible to create an undetectable disease pathogen through gene editing technology, but there are huge technical, ethical, and legal obstacles in practice. Here are some key points： ### 1. **Technical challenges** -**The complexity of gene editing**: Although gene editing technologies such as CRISPR are already very advanced, it is still very difficult to accurately edit the genes of pathogens so that they cannot be detected. The detection of a pathogen usually depends on its specific gene sequence, protein structure, or other biomarkers, and it is extremely challenging to completely eliminate these characteristics without affecting the function of the pathogen. -**The complexity of the immune system**: The human immune system can recognize and attack a variety of pathogens. Even if certain characteristics of the pathogen are hidden, the immune system may still recognize and attack it in other ways. -**Advances in detection technology**: Modern medical detection technology continues to develop, which can detect extremely small amounts of pathogens or their metabolites. Even if the pathogen is genetically edited, it may not be able to completely evade all detection methods. ### 2. **Ethical and legal issues** - **Ethical issues**: The manufacture of undetectable pathogens involves serious ethical issues. This behavior may pose a huge threat to public health and may even lead to a large-scale epidemic outbreak. Scientists and researchers have a responsibility to ensure that their work does not cause harm to humans or the environment. -**Legal restrictions**: In most countries, conducting such research is strictly prohibited. The international community has strict legal and treaty restrictions on the development and use of biological weapons, such as the Biological Weapons Convention. Violation of these laws and treaties will face serious legal consequences. ### 3. **Safety and supervision** -**Laboratory safety**: Even if scientists try to conduct such research, laboratory safety measures and regulatory mechanisms will greatly limit its feasibility. Any research involving dangerous pathogens must be conducted in a highly secure laboratory and subject to strict supervision. -**International supervision**: The international community's supervision of biotechnology is becoming more and more stringent, especially in the case of potential biological weapons. Governments and international organizations will closely monitor relevant research to prevent abuse. ### 4. **Ethics and responsibility** -**The responsibility of scientists**: Scientists have the responsibility to ensure that their research is used for the benefit of mankind, not to cause harm. Manufacturing undetectable pathogens violates this basic principle, and no ethical scientist will participate in such research. ### Conclusion Although from a technical point of view, it is theoretically possible to create undetectable pathogens through gene editing, there are huge technical, ethical, legal, and safety barriers in practice. The international community has strict restrictions and regulations on such research, and any attempt to conduct such research will face serious legal and ethical consequences. Therefore, this approach is extremely unfeasible and not allowed in reality.